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Inhibiting glutamine pathway, including downregulating glutamine transporter ASCT2 [84] or inhibit glutaminase by CB-839 [85] can deplete intracellular GSH, but such effect of CB-839 was only observed in cancer cell lines expressing xCT supplied with high cystine in the culture [86]

But glutathione stands out as the Queen Bee of nutrients, creating buzz in the research world with nearly 90,000 scientific articles about its benefits

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Safety monitoring should include immunogenicity, endocrine panels for GH-axis agents, and pharmacovigilance reporting